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Adrenaline suppression4/13/2023 For Diprosone Ointment (0.05%), the rate was 53%.įor Clobex lotion (clobetasol propionate), which was approved in 2003, 56% of adults in a small study of atopic dermatitis using the drug for two weeks had suppression. In one study of Diprolene AF Cream (0.05%) in 60 patients with atopic dermatitis, ages 1 to 12, 58% had adrenal suppression. The biggest problems seemed to be with betamethasone propionate, which was approved in 2001, and comes as a cream, ointment or lotion. The panel did not discuss any specific application, though GlaxoSmithKline representatives presented data from studies of consumer use of hydrocortisone creams.ĭenise Cook, M.D., a medical officer in FDA's Division of Dermatology and Dental Drug Products, presented data from studies in adults and children for 10 currently marketed topical corticosteroids. The committees were meeting to give advice on what data manufacturers would need to submit to convince the FDA that their products were safe to be sold over-the-counter. The suppression can lead to debilitating and potentially fatal conditions such as Cushing's syndrome.
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